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The verb ‘to desiccate’ is spelled thus, with one ‘-s-‘ and. two ‘-c-‘s. The same applies of course to its inflections ‘desiccated’, ‘desiccating’, etc., and derivatives such as desiccant.

It has the stress on the first syllable, ‘DES-sick-ate’. It means ‘to dry out’. If you know that the original adjective, the Latin siccus, has two ‘-c-‘s, you may remember the English spelling better.

Etymological note: desiccate comes from the Latin prefix de-, ‘thoroughly’ and verb siccare, ‘to dry’.